2023년 9월 11일
Secured delivery of basic fibroblast growth factor using human serum albumin-based protein nanoparticles for enhanced wound healing and regeneration
J. Nanobiotechnol., Sep 02 2023, 21 (1) 310 | https://doi.org/10.1186/s12951-023-02053-4
Secured delivery of basic fibroblast growth factor using human serum albumin-based protein nanoparticles for enhanced wound healing and regeneration.
Abstract
Background: Basic fibroblast growth factor (bFGF) is one of the critical components accelerating angiogenesis and tissue regeneration by promoting the migration of dermal fibroblasts and endothelial cells associated with matrix formation and remodeling in wound healing process. However, clinical applications of bFGF are substantially limited by its unstable nature due to rapid decomposition under physiological microenvironment.
Results: In this study, we present the bFGF-loaded human serum albumin nanoparticles (HSA-bFGF NPs) as a means of enhanced stability and sustained release platform during tissue regeneration. Spherical shape of the HSA-bFGF NPs with uniform size distribution (polydispersity index < 0.2) is obtained via a simple desolvation and crosslinking process. The HSA-bFGF NPs securely load and release the intact soluble bFGF proteins, thereby significantly enhancing the proliferation and migration activity of human dermal fibroblasts. Myofibroblast-related genes and proteins were also significantly down-regulated, indicating decrease in risk of scar formation. Furthermore, wound healing is accelerated while achieving a highly organized extracellular matrix and enhanced angiogenesis in vivo.
Conclusion: Consequently, the HSA-bFGF NPs are suggested not only as a delivery vehicle but also as a protein stabilizer for effective wound healing and tissue regeneration.
논문정보
- 형식: Research article
- 게재일: 2023년 09월 (BRIC 등록일 2023-09-08)
- 연구진: 국내(교신)+국외 연구진
- 분야: 생명과학 > 생물공학
관련 인터뷰
'Basic fibroblast growth factor(bFGF)'는 손상된 조직 및 상처를 치유하는데 중요한 역할을 하는 성장인자로서, 조직공학 및 재생의학 분야에서 각광받는 물질 중 하나입니다. bFGF는 진피 섬유아세포(human dermal fibroblast, HDF)의 증식 및 이동성 증진을 통해 손상된 조직의 새로운 기질 형성을 도울 뿐 만 아니라, 내피세포(endothelial cell)의 발달을 촉진함으로써...